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IGF-1 signaling also plays a role in maintaining BBB integrity by promoting the expression of tight junction proteins and inhibiting the breakdown of the extracellular matrix (Freese et al., 2017)
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Individuals with metabolic conditions often have altered metabolism, insulin resistance and hormonal imbalances (Reference Roberts, Hevener and Barnard48) , which might reduce the impact of tea and coffee constituents on weight reduction
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These lifestyle changes may also promote quality sleep
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